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What You Inherit
Genetic risk from your family tree — no DNA test needed
What You Inherit infers latent genotypes and genetic-disease risk from a pedigree — no genetic test required. Enter a family tree plus whatever clinical detail exists, and get exact Bayesian posteriors over which disease is segregating, each relative's carrier probability and lifetime risk, and the variant they likely carry.
Hey Product Hunt 👋 We're launching whatyouinherit — a tool that works out what a family likely inherited genetically, using only the family tree and whatever clinical detail already exists. No DNA test required.
The problem it solves: most tools either rank diseases by symptom similarity then apply a textbook risk figure, or assume you already have genetic data. Both throw away the strongest signal in a family — how the phenotype actually segregates through the pedigree.
What's different:
A joint Bayesian model over disease identity, latent genotypes and observed phenotypes — exact inference (variable elimination / junction tree), not sampling or a phenotype-similarity score
Age-dependent penetrance and onset learned from the family's own ages, so an unaffected 70-year-old counts as evidence against a dominant allele — an unaffected 20-year-old doesn't
Handles consanguinity, imprinting (14 disorders), digenic inheritance, germline mosaicism, hereditary cancer (BRCAPRO-style model), common multifactorial conditions, and "two conditions at once"
Negative test results are weighted by what the assay can miss — a negative HTT test leaves 0.99% risk if targeted, 9.1% if a panel, never a false 0%
It ships with a CLI, a Python API, and a browser pedigree builder where you can describe your family in plain language (Chinese or English) and it fills the tree in — with every ID validated against the compiled database before the numbers are run.
Validated, with baselines: beats "Mendelian, given the true diagnosis" on calibration by ~3x (ECE 0.085 vs 0.198), and reproduces textbook genetic-counselling hand calculations — the mother of an isolated Duchenne boy carries it 2/3 of the time, exactly as Haldane's argument says.
Full source (MIT) + 10k+ lines of validation in the repo. Would love feedback from anyone working in genomics, clinical genetics, or family-history tooling. What would you want to see next?
About What You Inherit on Product Hunt
“Genetic risk from your family tree — no DNA test needed”
What You Inherit was submitted on Product Hunt and earned 2 upvotes and 1 comments, placing #155 on the daily leaderboard. What You Inherit infers latent genotypes and genetic-disease risk from a pedigree — no genetic test required. Enter a family tree plus whatever clinical detail exists, and get exact Bayesian posteriors over which disease is segregating, each relative's carrier probability and lifetime risk, and the variant they likely carry.
On the analytics side, What You Inherit competes within Health & Fitness, SaaS and Medical — topics that collectively have 131.9k followers on Product Hunt. The dashboard above tracks how What You Inherit performed against the three products that launched closest to it on the same day.
Who hunted What You Inherit?
What You Inherit was hunted by Hao. A “hunter” on Product Hunt is the community member who submits a product to the platform — uploading the images, the link, and tagging the makers behind it. Hunters typically write the first comment explaining why a product is worth attention, and their followers are notified the moment they post. Around 79% of featured launches on Product Hunt are self-hunted by their makers, but a well-known hunter still acts as a signal of quality to the rest of the community. See the full all-time top hunters leaderboard to discover who is shaping the Product Hunt ecosystem.
For a complete overview of What You Inherit including community comment highlights and product details, visit the product overview.
Hao